Nabota® Botulinum toxin type A is indicated for the temporary improvement in the appearance of the upper respiratory tract (forehead lines, crow’s feet and forehead lines) in adults. Botulinum toxin type A (Nabota®) is indicated for the prevention of headaches in adults with chronic migraine.
NABOTA® is intended for intramuscular injection by a licensed medical professional. Proper dilution and anatomical knowledge are critical for safe and effective treatment.
Key features:
Administered at five injection sites in the glabellar complex
Standard dose: 20 Units total (4 Units per site)
Injection protocol:
Reconstitute 100 Units with 2.5 mL preservative-free 0.9% NaCl (yields 4 Units per 0.1 mL)
Inject 0.1 mL (4 Units) at each of:
Inferomedial corrugator (left and right)
Superior corrugator (left and right)
Midline of procerus
Avoid injections <1 cm above central eyebrow to minimize ptosis risk
Use within 24 hours post-reconstitution; refrigerate at 2–8°C
Indications:
Temporary improvement of moderate to severe glabellar lines in adults
Contraindications:
Hypersensitivity to any botulinum toxin product
Infection at proposed injection site(s)
Potential side effects:
Very common: Headache (12%)
Common: Eyelid ptosis (2%), upper respiratory tract infection (3%)
Other: Injection site pain, local weakness, eyelid swelling, allergic reactions
Serious adverse events may include dysphagia, respiratory distress, and systemic toxin spread (rare but potentially life-threatening).






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