Hyalase Ampoules 1500 IU
Hyalase is a sterile hyaluronidase powder for solution used by healthcare professionals to increase the dispersion and absorption of injected fluids and medicines. By temporarily breaking down hyaluronic acid in the extracellular matrix, Hyalase reduces tissue viscosity so that subcutaneous fluids, local anaesthetics and other compatible injectables can spread more readily. Clinically, it’s used as an adjuvant to local infiltration, to facilitate subcutaneous infusions (hypodermoclysis), to aid the management of non-caustic extravasation, and—where clinically indicated—by trained clinicians in aesthetics to dissolve hyaluronic acid dermal fillers. Each box contains 5 ampoules/vials, each with 1500 international units (IU) ready to be reconstituted immediately before use.
Active Ingredients
Hyaluronidase 1500 IU per ampoule (powder for solution for injection/infusion).
Excipients: see carton/leaflet. Reconstitution solvent is not included; prepare with a suitable sterile diluent as directed by the product information.
Reasons to Use
As an adjuvant to improve the spread and uptake of subcutaneous or intramuscular injections (e.g., local anaesthetics used in infiltration).
To facilitate subcutaneous fluid administration (hypodermoclysis) by reducing tissue resistance.
To assist the management of non-vesicant extravasation by promoting dispersion of infiltrated solutions, as per local protocols.
In qualified hands, to degrade hyaluronic acid dermal fillers when medically indicated (e.g., vascular compromise, overcorrection, asymmetry).
Reasons Not to Use
Hypersensitivity to hyaluronidase or any component of the product.
Active infection or inflamed/fragile tissue at the intended site of injection.
History of anaphylaxis or significant allergies; use only with appropriate precautions.
Do not inject intravenously or into areas where enhanced spread could be harmful.
Use with caution in patients with conditions where increased systemic absorption of co-administered drugs may be undesirable.
Not intended for self-administration; professional assessment, dosing and technique are essential.
Advantages
Enhances diffusion of compatible injectates for more predictable local effect.
May reduce tissue pressure and discomfort during subcutaneous infusions.
Versatile: medical, surgical, and aesthetic applications when used by trained professionals.
Unit-dosed ampoules support aseptic preparation at the point of care.
Disadvantages
Requires reconstitution and strict aseptic technique.
Risk of allergic reactions, including rare anaphylaxis—monitor patients after administration.
Can increase systemic absorption of co-administered medicines; interaction awareness is required.
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